At a cellular level, an increase in the ventricular action potential duration (APD) with a subsequent increase in early afterdepolarizations (EADs) underlies long QT–associated torsades de pointes ventricular arrhythmias ( 10).ĭM is associated with elevated inflammatory cytokines and mitochondrial oxidative stress. QT prolongation has been associated with sudden cardiac death in type 2 DM (T2DM), suggesting that electrical remodeling in DM may contribute to ventricular arrhythmias and sudden cardiac death ( 7–9). Clinical studies demonstrated a high prevalence of QT prolongation in DM patients ( 6). The risk of sudden cardiac death in DM is double that of nondiabetic persons ( 4).Ī prolonged QT interval on the surface electrocardiogram is a risk factor for sudden cardiac death ( 5). Roughly 70% of patients with DM die from cardiovascular causes ( 2), of which around 50% are sudden cardiac deaths ( 3). In 2016, an estimated 1.6 million deaths were caused directly by DM ( 1). More than 400 million people worldwide have diabetes mellitus (DM).
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Here you can download Poly Bridge 2 for free! On this page you will find information about Poly Bridge 2 and how you can download the game for free.
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